- Light Yagami (Kira) (夜神 月, Yagami Raito)
- The protagonist of Death Note, Light is an extremely intelligent, popular and athletic, but bored 17-year old student. When he finds the Death Note, dropped in the human world by Ryuk (a shinigami), he decides to use it to kill all criminals and earns the title Kira. His ultimate goal is to cleanse the world of evil to create a utopia and then reign over this new world as its god.
L (エル, Eru, L Lawliet)- L is the world's top-rated detective, tasked with tracking down and arresting Kira. As such, he is Light's arch-enemy. His disheveled appearance masks his great powers of deduction and insight. L has many quirks, such as sitting in an odd manner, snacking on sweets constantly, and holding objects in a peculiar manner. He often takes drastic strategies to confuse and force the hand of his opponents. On several occasions he has willingly disclosed several of his weaknesses to Kira at the risk of his own life in the hopes that he would lure him into a trap.
- Misa Amane (弥 海砂, Amane Misa)
- A girl with an immense crush on Kira, Misa is a popular idol in Japan. She is immature and tends to refer to herself in the third person in an attempt to be cute. Misa is completely devoted to Light, and she once said that she loved him at first sight. Light, however, only views her as an asset to his plans because of her Death Note and her Shinigami eyes (that she obtained at the cost of half of her remaining life span, twice). Misa devotes herself to Light because he killed her parents' murderer after several trials had failed to convict him
Mello (メロ, Mero, Mihael Keehl)
- Mello was an orphan who grew up with Near in Watari's shelter for gifted children. Like Near, Mello was one of the candidates to become L's successor. Similar to L's fondness for sweets, he is often seen eating bars of chocolate. Although Mello is quite intelligent, he often lets his emotions get the better of him. Mello wears leather most of the time, unlike Near or L. He also appears to be less secluded in terms of his friends and hobbies, and seems to be fond of biking.
- Near (ニア, Nia, Nate River)
- Near was a primary candidate to become L's successor and calls himself N during the course of his investigations. He shares a number of similarities with L. Much like how L plays with things
- such as sugar cubes and forks, Near is frequently shown playing with toys or his hair. Near also sits in an unusual manner similar to L, but with some slight differences. He offered to join forces with Mello to fight Kira, but Mello turned him down. Near then gained the support of the Government of the United States and formed the Special Provision for Kira (SPK).
Mikami is selected as the fourth Kira by Light, after Light decides that it is too dangerous for the Death Note to be near Misa or himself, since he and Misa are currently under surveillance by Aizawa and Mogi. A prosecuting attorney and adamant supporter of Kira, Mikami shares many of the same ideals, thoughts, and priorities as Kira, and is ecstatic when he discovers that Kira, his God, has chosen him, proving that God is on his side and watching. He is completely devoted and loyal to Kira, believing that divine justice must be brought down upon the people. Little is known about his personal life; he appears to have no hobbies or anything else of the sort. He chants "delete" with each name he writes down in the Death Note due to events in his past when he thought God was "deleting" the evil people in his life. He, like Misa, has made theexchange of half his remaining years for Shinigami eyes.
Ryuk (リューク, Ryūku)
- A shinigami who dropped a Death Note into the human world, which Light would pick up. Acting out of pure boredom, Ryuk begins the story of Death Note on a whim. It is stated that Ryuk obtained the second Death Note in the shinigami world from "tricking the old man" for another one. Ryuk is not Light's ally, and in fact declares in their first meeting that someday he (Ryuk) would write Light's name into his own Death Note. Ryuk often refuses to aid Light and instead enjoys watching him struggle for his goals. He acts for his own interests and entertainment, and often fails to tell Light key details about the Death Note. However, Ryuk will aid Light if it serves his own goals, such as providing amusement or obtaining apples, without which he suffers a form of withdrawal symptoms.
- Rem (レム, Remu)
- The female shinigami who first gives Misa her Death Note and trades her for the Shinigami eyes. Similar to Ryuk, Rem possesses two Death Notes; however, she purposely gives one of them to Misa Amane. Rem inherited her second Death Note from Gelus, another shinigami who died when he saved Misa's life, and thought it only right to pass it on to Misa. Rem inherits Gelus' love for Misa as well and is prompt to defend Misa even at the cost of her life. Rem shows this when she states that she will kill Light if Misa dies before her time.
- Sidoh (シドウ, Shidō)
- The third shinigami seen in the human world, Sidoh is revealed as the original owner of the Death Note Ryuk dropped at the beginning of the series. Initially upon entering the human world, Sidoh relentlessly follows Ryuk, demanding the return of his Death Note. Ryuk eventually admits he has no knowledge of the location of Sidoh's Death Note, said note having been used as a bargaining chip by Light and fallen into Mello's hands. Sidoh eventually locates his Death Note, and, under questioning, reveals to Mello (who subsequently reveals to Near) that some of the rules written in the Death Note are fake. The English versions of the series and the Japanese volumes use the romanization Sidoh while the Japanese Death Note 13: How to Read book uses the romanization Shidoh.